Backpack Black MCM Stark Stark Backpack Black MCM Stark MCM InqwFx7Bwz
Incessantly modern in its design approach, MCM fuses its emblematic print with contemporary shapes and practical details. Cut from the label's signature Visetos coated canvas, this backpack is distinguished by the metallic studs adorned on each side and the grungy gun metal toned hardware, while the front zipped pouch, streamlined side pockets and large interior are perfect for on the go organising. (Height 36cm, width 26cm, depth 17cm)MCM backpack Zip fastening Front zipped pouch, two side slip pockets, top handle, adjustable padded mesh shoulder straps, silver toned hardware, gun metal toned hardware, embellished studs, logo plaque, two interior slip pockets, contrast lining70% PVC, 30% PU100% leather trims Use specialist cleaner Height 36cm, width 26cm, depth 17cm
Stark Black Stark Stark MCM MCM Black MCM Backpack Backpack Backpack Stark Black Black MCM MCM Stark Stark MCM Backpack Stark Black MCM Stark Backpack MCM Black MCM Backpack Stark
2002 Sep 27;297(5590):2275-9.

Abstract

Celiac Sprue, a widely prevalent autoimmune disease of the small intestine, is induced in genetically susceptible individuals by exposure to dietary gluten. A 33-mer peptide was identified that has several characteristics suggesting it is the primary initiator of the inflammatory response to gluten in Celiac Sprue patients. In vitro and in vivo studies in rats and humans demonstrated that it is stable toward breakdown by all gastric, pancreatic, and intestinal brush-border membrane proteases. The peptide reacted with tissue transglutaminase, the major autoantigen in Celiac Sprue, with substantially greater selectivity than known natural substrates of this extracellular enzyme. It was a potent inducer of gut-derived human T cell lines from 14 of 14 Celiac Sprue patients. Homologs of this peptide were found in all food grains that are toxic to Celiac Sprue patients but are absent from all nontoxic food grains. The peptide could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for Celiac Sprue.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Support Center